- If you eat something new or unusual for you, you may experience a lingering mouthfeel, that keeps drawing your attention back in stolen moments. This may be phenomenology that is involved in the immune system’s epitope-level inferencing to learn and unlearn possible threats.
- For epitopes that have been detected in the mouth, the immune system provisionally considers them less likely to be a replicating invader (because, even if they’re in high concentration, those epitopes could simply have come from food and may be inert/harmless).
- The immune system may even do certain kinds of integrative deltas, comparing epitopes detected in the mouth versus the lower intestine.
- Some of this inferencing is at the “molecular and cellular machinery” level, but, some of this inferencing is “fully general,” seamless, contiguous, coextensive with high-level “everyday” cognition, and this feeds back into the low-level system.
- Both the innate and adaptive immune systems can be top-down modulated (down to the epitope level, at the very least for the adaptive immune system) by high-level percepts and beliefs.
- It follows that immune system underreaction and overreaction, when molecular machinery and nervous system innervation are intact, can be progressively corrected through introspective/interoceptive tools such as meditation.
- (Tangentially, nutritive/energy inferencing & food motivation, through deconvolution of flavor, & other mouth sensations, combined w interoceptive phenomenology over minutes, hours, & days, etc. (Hours later: “mmm that was such a good meal.”), is just as fine-grain & malleable.)
- (Additionally, energy metabolism—energy conservation and burn rate, and thus felt energy & e.g. mood—insulin response, insulin resistance, basal metabolic rate, etc., while highly entrained by mechanical and hormetic influences, are also malleable, top-down influenced.)
- Modulo privilege & opportunity cost, across MANY(/all?) dimensions, seemingly low-level physiological machinery & instinctual motivations are “open,” dramatically malleable, the progressive optimization of which culminates in ever more “autonomic harmony” & felt robust wellbeing.
If you eat something new or unusual for you, you may experience a lingering mouthfeel, that keeps drawing your atte… twitter.com/i/web/status/1…—
Mark (👨💻's meditation instructions (See 🔗s👇)) (@meditationstuff) January 19, 2021